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Collin Bogle
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| Fes | Дата: Понедельник, 07.03.2011, 13:51:03 | Сообщение # 1 |
 Мастер
Группа: Обитатель
Сообщений: 494
Награды: 1
Репутация: 9
Статус: Странствует
| Рисунок, который сделал Collin Bogle - красивый и ну очень реалистичный. Колин использует пастель, цветные карандаши, акварель и акрил. Эти великолепные работы принесли ему заслуженную популярность и авторитет во всем мире.   
  
  
  
 
  
Дано Вам право, - верьте в чёрта!
Глупы Вы были, и быть может есть,
Но жаль, забыли вы немножко,
О том, что есть такое, - честь...
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| famuyiyaob | Дата: Среда, 04.02.2015, 22:29:16 | Сообщение # 2 |
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Группа: Заблудший
| Vancomycin INN /v??k??ma?s?n/ is a glycopeptide antibiotic tempered to in the prophylaxis and treatment of infections caused by means of Gram-positive bacteria. Vancomycin was maiden isolated in 1953 at Eli Lilly, from a begrime representation nonchalant from the personal jungles of Borneo by a missionary. It is a consequently occurring antibiotic made close to the tarnish bacterium Actinobacteria species Amycolatopsis orientalis(in days designated Nocardia orientalis). It is a complex chemical mix and an illustration of a comparatively rare haloorganic realistic complex, containing two covalently bonded chlorine atoms.
The compound was industrially produced at near fermentation and assumed the generic name vancomycin, derived from the stretch "vanquish." The primeval sign seeing that vancomycin was throughout the treatment ofpenicillin-resistant Staphylococcus aureus, a consume kept astir in behalf of many years via the low-down that compound had to be accustomed intravenously and that being so provided bacteria fewer opportunities to evolve freedom fighters, and the in truth that organisms were comparatively boeotian to evolve to reshape to it, orderly in experiments.
To go to many years since its original demand, vancomycin had traditionally been distant as a drug of "matrix remedy have recourse to" straight membership fee to cock's-crow observations of its nephrotoxicity and ototoxicity as accurately as its intravenous dosing requirements.<> - Recently, however, vancomycin intractable organisms are stylish common. Ergo, vancomycin is increasingly being displaced from this role on newer antibiotics such as linezolid(Zyvox), daptomycin (Cubicin), and quinupristin/dalfopristin (Synercid).
Recapitulation
Vancomycin was foremost secluded in 1953 during Edmund Kornfeld (working at Eli Lilly) from a soil try unruffled from the interior jungles of Borneo by way of a missionary.<> - The living thing that produced it was when all is said named Amycolatopsis orientalis.<> - The original clues by reason of vancomycin was in search the treatment of penicillin-resistant Staphylococcus aureus.<> - <> -
The go together was initially called parathesis 05865, but was in the final analysis assumption the generic namevancomycin, derived from the arrange "vanquish".<> - At one gain that was quickly apparent is that staphylococci did not evolve substantive guerillas despite serial thoroughfare in enlightenment media containing vancomycin. The brisk happening of penicillin resistance by staphylococci led to the heighten's being fast-tracked on approval by the Nutriment and Narcotic Administration (FDA) in 1958. Eli Lilly first marketed vancomycin hydrochloride beneath the clientele moniker Vancocin<> - and as COVANC from Nucleus, India.<citation>needed -
Vancomycin never became the first-line treatment in behalf of Staphylococcus aureus for a variety of reasons:
1. It possesses meagre oral bioavailability; it ought to be specified intravenously as a service to most infections.
2. β-Lactamase-resistant semi-synthetic penicillins such as methicillin (and its successors,nafcillin and cloxacillin) were afterwards developed, which bear better vocation against non-MRSA staphylococci.
3. Ahead of time trials cast-off initial impure forms of vancomycin ("Mississippi mud"), which were develop to be toxic to the ears and to the kidneys;<> - these findings led to vancomycin's being relegated to the state of a drug of last resort.<> -
In 2004, Eli Lilly licensed Vancocin to ViroPharma in the U.S., Flynn Pharma in the UK, and Aspen Pharmacare in Australia. The plain expired in the initially 1980s; the FDA authorized the sale of sundry generic versions in the USA, including from manufacturers Bioniche Pharma, Baxter Healthcare, Sandoz, Akorn Strides and Hospira.<> -
An uttered cast of vancomycin was initially approved by the FDA in 1986 as the treatment of Clostridium difficile induced pseudomembranous colitis. It is not orally absorbed into the blood and remains in the gastrointestinal zone to eradicate C. difficile. This effect is currently marketed during ViroPharmain the USA.<> -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| fmyykjf | Дата: Понедельник, 02.03.2015, 18:36:40 | Сообщение # 3 |
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Группа: Заблудший
| Daptomycin is a cyclic lipopeptide antibiotic produced by the body Streptomyces roseosporus.<>4 - <>5 - Daptomycin consists of thirteen amino acids, ten of which are arranged in a cyclic fashion, and three that adorn an exocyclic tail. Two non-proteinogenic amino acids an existence in the lipopeptide, the unusual amino acid L-kynurenine (Kyn), no more than known to Daptomycin, and L-3-methylglutamic acid (mGlu). The N-terminus of the exocyclic tryptophan dregs is coupled to decanoic acid, a medium limit (C10) fatty acid. Biosynthesis is initiated alongside the coupling of decanoic acid to the N-terminal tryptophan, followed by means of the coupling of the leftover amino acids not later than nonribosomal peptide synthetase (NRPS) mechanisms. Finally, a cyclization outcome occurs, which is catalyzed past a thioesterase enzyme, and subsequent disseminate of the lipopeptide is granted.
The non-ribosomal peptide synthetase (NRPS) liable for the synthesis of Daptomycin is encoded by three overlapping genes, dptA, dptBC and dptD. The dptE and dptF genes, in a second upstream of dptA, are favoured to be snarled in the installation of daptomycin biosynthesis on coupling decanoic acid to the N-terminal Trp.<>6 - These novel genes (dptE, dptF ) be in touch to products that most able under way in conjunction with a incomparable condensation realm to acylate the original amino acid (tryptophan). These and other creative genes (dptI, dptJ) are believed to be confused in supplying the non-proteinogenic amino acids L-3-methylglutamic acid and Kyn; they are located next to the NRPS genes.<>6 -
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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